15-P002 Limbs gone batty: A second wave of Sonic hedgehog expression during the development of the bat limb
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چکیده
منابع مشابه
15-P002 Limbs gone batty: A second wave of Sonic hedgehog expression during the development of the bat limb
The first lineage allocation during mouse development results in the trophectoderm and inner cell mass at the blastocyst stage. The caudal-related transcription factor, CDX2, is upregulated and required for the repression of inner cell mass genes Oct 4 and Nanog in the trophectoderm to specify the two lineages. Mouse embryos are precocious implanters requiring early establishment of trophectode...
متن کاملA second wave of Sonic hedgehog expression during the development of the bat limb.
Sonic hedgehog (Shh) plays an integral role in both the anterior-posterior (A-P) patterning and expansion of developing vertebrate limbs through a feedback loop involving Fgfs, Bmps, and Gremlin. In bat limbs A-P patterning and the size of the digital field are unique. The posterior digits of the forelimb are elongated and joined by tissue, whereas the thumb is short. The hindlimb digits often ...
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ژورنال
عنوان ژورنال: Mechanisms of Development
سال: 2009
ISSN: 0925-4773
DOI: 10.1016/j.mod.2009.06.646